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In cats, black fur color is caused by an X-linked allele; the other allele at this locus causes orange color. The heterozygote is tortoiseshell. What kinds of offspring would you expect from the cross of a black female and an orange male?


A) Tortoiseshell females; tortoiseshell males
B) Black females; orange males
C) Orange females; orange males
D) Tortoiseshell females; black males
E) Orange females; black males

F) All of the above
G) C) and D)

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The frequency of crossing over between any two linked genes will be which of the following?


A) Higher if they are recessive
B) Dependent on how many alleles there are
C) Determined by their relative dominance
D) The same as if they were not linked
E) Proportional to the distance between them

F) A) and C)
G) C) and D)

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The frequency of Down syndrome in the human population is most closely correlated with which of the following?


A) Frequency of new meiosis
B) Average of the ages of mother and father
C) Age of the mother
D) Age of the father
E) Exposure of pregnant women to environmental pollutants

F) B) and C)
G) C) and E)

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Cinnabar eyes is a sex-linked recessive characteristic in fruit flies. If a female having cinnabar eyes is crossed with a wild-type male, what percentage of the F1 males will have cinnabar eyes?


A) 0%
B) 25%
C) 50%
D) 75%
E) 100%

F) A) and C)
G) All of the above

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SRY is best described in which of the following ways?


A) A gene region present on the Y chromosome that triggers male development
B) A gene present on the X chromosome that triggers female development
C) An autosomal gene that is required for the expression of genes on the Y chromosome
D) An autosomal gene that is required for the expression of genes on the X chromosome
E) Required for development, and males or females lacking the gene do not survive past early childhood

F) B) and C)
G) A) and D)

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Why did the improvement of microscopy techniques in the late 1800s set the stage for the emergence of modern genetics?


A) It revealed new and unanticipated features of Mendel's pea plant varieties.
B) It allowed the study of meiosis and mitosis, revealing parallels between behaviors of genes and chromosomes.
C) It allowed scientists to see the DNA present within chromosomes.
D) It led to the discovery of mitochondria.
E) It showed genes functioning to direct the formation of enzymes.

F) A) and B)
G) A) and E)

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Morgan and his colleagues worked out a set of symbols to represent fly genotypes. Which of the following are representative?


A) AaBb × AaBb
B) 46, XY or 46, XX
C) vg+vgse+se × vgvgsese
D) +2 × +3

E) B) and C)
F) A) and C)

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In another cross, a wild-type fruit fly (heterozygous for gray body color and red eyes)is mated with a black fruit fly with purple eyes. The offspring are as follows: wild type, 721; black-purple, 751; gray-purple, 49; black-red, 45. What is the recombination frequency between these genes for body color and eye color? Using information from problem 4, what fruit flies (genotypes and phenotypes)would you mate to determine the sequence of the body-color, wing-size, and eye-color genes on the chromosome?

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6%. Wild type (heterozygous fo...

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You design Drosophila crosses to provide recombination data for gene a, which is located on the chromosome shown in Figure 15.12 in the textbook. Gene a has recombination frequencies of 14% with the vestigial-wing locus and 26% with the brown-eye locus. Where is a located on the chromosome?

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About one-third of t...

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What is the mechanism for the production of genetic recombinants?


A) X inactivation
B) Methylation of cytosine
C) Crossing over and independent assortment
D) Nondisjunction
E) Deletions and duplications during meiosis

F) A) and E)
G) None of the above

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Bananas plants, which are triploid, are seedless and therefore sterile. Propose a possible explanation.

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Because bananas are triploid, homologous...

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What pattern of inheritance would lead a geneticist to suspect that an inherited disorder of cell metabolism is due to a defective mitochondrial gene?

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The disorder would a...

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What is the chromosomal system for determining sex in mammals?


A) Haploid-diploid
B) X-0
C) X-X
D) X-Y
E) Z-W

F) B) and D)
G) A) and D)

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In humans, male-pattern baldness is controlled by an autosomal gene that occurs in two allelic forms. Allele Hn determines nonbaldness, and allele Hb determines pattern baldness. In males, because of the presence of testosterone, allele Hb is dominant over Hn. If a man and woman both with genotype HnHb have a son, what is the chance that he will eventually be bald?


A) 0%
B) 25%
C) 33%
D) 50%
E) 75%

F) A) and D)
G) C) and D)

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Correns described that the inheritance of variegated color on the leaves of certain plants was determined by the maternal parent only. What phenomenon does this describe?


A) Mitochondrial inheritance
B) Chloroplast inheritance
C) Genomic imprinting
D) Infectious inheritance
E) Sex-linkage

F) A) and B)
G) A) and C)

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B

A man with hemophilia (a recessive, sex-linked condition)has a daughter of normal phenotype. She marries a man who is normal for the trait. What is the probability that a daughter of this mating will be a hemophiliac? That a son will be a hemophiliac? If the couple has four sons, what is the probability that all four will be born with hemophilia?

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0; 1⁄2, 1/16

Which of the following statements describes genomic imprinting?


A) It explains cases in which the gender of the parent from whom an allele is inherited affects the expression of that allele.
B) It is greatest in females because of the larger maternal contribution of cytoplasm.
C) It may explain the transmission of Duchenne muscular dystrophy.
D) It involves an irreversible alteration in the DNA sequence of imprinted genes.

E) A) and B)
F) A) and C)

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Map units on a linkage map cannot be relied upon to calculate physical distances on a chromosome for which of the following reasons?


A) The frequency of crossing over varies along the length of the chromosome.
B) The relationship between recombination frequency and map units is different in every individual.
C) Physical distances between genes change during the course of the cell cycle.
D) The gene order on the chromosomes is slightly different in every individual.
E) Linkage map distances are identical between males and females.

F) A) and B)
G) All of the above

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What is the source of the extra chromosome 21 in an individual with Down syndrome?


A) Nondisjunction in the mother only
B) Nondisjunction in the father only
C) Duplication of the chromosome
D) Nondisjunction or translocation in either parent
E) It is impossible to detect with current technology

F) A) and C)
G) B) and D)

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What is the chromosomal system of sex determination in most species of ants and bees?


A) Haploid-diploid
B) X-0
C) X-X
D) X-Y
E) Z-W

F) A) and E)
G) A) and B)

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A

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