Question 1

What kinds of mutations can be revealed through ultrasound?

Accepted Answer

A)   Some chromosomal abnormalities, such as Down syndrome and Edwards syndrome, and a few other known inherited disorders.
B)   The genetic profile, including any mutant gene alleles the fetus may have.
C)   All chromosomal mutations, including deletions, duplications, inversions, and translocations.
D)   Only larger chromosomal mutations, such as the large deletion seen in individuals with cri du chat syndrome.
E)   Only inherited genetic disorders caused by single gene mutations.F) C) and E)
G) A) and D) A

Question 2

What is a possible inheritance pattern for the pedigree shown here?

Accepted Answer

A)   autosomal dominant
B)   autosomal recessive
C)   X-linked recessive
D)   could be autosomal recessive or X-linked recessive
E)   X-linked dominantF) A) and C)
G) A) and B)

Question 3

A man has an X-linked dominant genetic disorder. If he has a daughter with an unaffected woman, what is the probability that the daughter will inherit the disorder?

Accepted Answer

A)   0%
B)   25%
C)   50%
D)   75%
E)   100%F) A) and B)
G) A) and C)

Question 4

Figure: 
-You are a genetic counselor, and a man with the translocation shown in the figure is your client. He and his partner (who has a normal karyotype)  wish to have children. You explain to him that the probability of having a child with the same translocation as the father is _______.

Accepted Answer

A)   0%
B)   25%
C)   50%
D)   75%
E)   100%F) A) and D)
G) All of the above

Question 5

What are the current known methods of delivering genes to cells for gene therapy?

Accepted Answer

A)   viruses, liposomes, and nasal sprays
B)   viruses, nasal sprays, and gene guns
C)   liposomes, nasal sprays, and chemical transformation
D)   nasal sprays, liposomes, and gene guns
E)   viruses and gene gunsF) A) and B)
G) A) and C) A

Question 6

A karyotype shows chromosomes arranged by

Accepted Answer

A)   banding patterns, size, and shape.
B)   shape, size, and complexity.
C)   complexity, radius, and length.
D)   length, structure, and color.
E)   color, width, and length.F) None of the above
G) C) and E)

Question 7

If the mode of inheritance for the pedigree shown here is X-linked dominant, what is/are the possible phenotype(s)  of the individual marked with a *? BXB B)  XBXb C)  XbXb D)  XBXB or XBXb E)  cannot be determined" class="answers-bank-image d-inline" rel="preload" >

Accepted Answer

A)   XBXB
B)   XBXb
C)   XbXb
D)   XBXB or XBXb
E)   cannot be determinedF) A) and B)
G) C) and E)

Question 8

A DNA microarray detects

Accepted Answer

A)   mutant gene alleles associated with disease.
B)   an individual's complete genotype, including all the various mutations.
C)   chromosomal abnormalities, such as duplications or deletions.
D)   fetal cells in the mother's blood.
E)   viral DNA in an individual's cells.F) D) and E)
G) None of the above

Question 9

Amniocentesis may be preferred over chorionic villus sampling (CVS)  for karyotyping because

Accepted Answer

A)   CVS is a less invasive procedure and has a faster recovery time.
B)   amniocentesis can be performed more quickly than CVS.
C)   CVS carries a lower risk of miscarriage than amniocentesis.
D)   a larger amount of tissue may be taken, allowing the results to be obtained more quickly.
E)   amniocentesis may be performed at an earlier stage of pregnancy and so the risk of miscarriage is higher.F) B) and D)
G) All of the above

Question 10

A woman has an X-linked recessive trait. What must her mother's genotype be?

Accepted Answer

A)   XbXb
B)   XBXB
C)   XBXb or XbXb
D)   XBXB or XbXb
E)   XBXB or XBXbF) B) and E)
G) B) and C)

Question 11

Mutant gene alleles associated with known genetic disorders can be detected using DNA microarray analysis.

Accepted Answer

A) True 
 B)False

Question 12

Sickle cell disease and cystic fibrosis both exhibit what mode of inheritance?

Accepted Answer

A)   X-linked recessive
B)   autosomal dominant
C)   Y-linked recessive
D)   autosomal recessive
E)   X-linked dominantF) A) and D)
G) B) and E)

Question 13

All sons of a man with a Y-linked disorder will also show the disorder.

Accepted Answer

A) True 
 B)False

Question 14

Ex vivo gene therapy differs from in vivo gene therapy in that

Accepted Answer

A)   ex vivo gene therapy involves directly introducing the gene into the body.
B)   in vivo gene therapy involves directly introducing the gene into the body.
C)   in vivo gene therapy only employs viruses for gene transfer.
D)   ex vivo gene therapy only employs viruses for gene transfer.
E)   ex vivo gene therapy can employ viruses, nasal sprays, or liposomes for gene transfer, but only liposomes may be used for in vivo gene therapy.F) B) and D)
G) None of the above

Question 15

In pedigrees of autosomal dominant traits, every affected child must have at least one affected parent.

Accepted Answer

A) True 
 B)False  True

Question 16

Figure: 
-You are a genetic counselor, and a man with the translocation shown in the figure is your client. He and his partner (who has a normal karyotype)  wish to have children. You explain to him that the probability of having a child with a normal karyotype is _______.

Accepted Answer

A)   0%
B)   25%
C)   50%
D)   75%
E)   100%F) A) and B)
G) B) and D)

Question 17

Testing for a protein may help reveal whether or not an individual has a genetic disorder.

Accepted Answer

A) True 
 B)False

Question 18

A parent has a deletion on one homologue of a pair of chromosomes. What is the probability of this individual's child carrying the same deletion?

Accepted Answer

A)   0%
B)   25%
C)   50%
D)   75%
E)   100%F) A) and B)
G) All of the above

Question 19

Chorionic villus sampling carries less risk of causing miscarriage than amniocentesis.

Accepted Answer

A) True 
 B)False

Question 20

A pedigree chart is an important tool for a genetic counselor because

Accepted Answer

A)   it provides the genotype of all the family members.
B)   it shows the family history for one genetic trait.
C)   it shows whether a child will have a genetic disorder or not.
D)   it does not reveal the sexes of the individuals.
E)   it reveals the mode of inheritance of any particular genetic trait.F) C) and E)
G) All of the above

Exam 13: Genetic Counseling

What kinds of mutations can be revealed through ultrasound?

Correct AnswerverifiedA

What is a possible inheritance pattern for the pedigree shown here?

Correct AnswerverifiedShow Answer

A man has an X-linked dominant genetic disorder. If he has a daughter with an unaffected woman, what is the probability that the daughter will inherit the disorder?

Correct AnswerverifiedShow Answer

Figure: -You are a genetic counselor, and a man with the translocation shown in the figure is your client. He and his partner (who has a normal karyotype) wish to have children. You explain to him that the probability of having a child with the same translocation as the father is _______.

Correct AnswerverifiedShow Answer

What are the current known methods of delivering genes to cells for gene therapy?

Correct AnswerverifiedA

A karyotype shows chromosomes arranged by

Correct AnswerverifiedShow Answer

If the mode of inheritance for the pedigree shown here is X-linked dominant, what is/are the possible phenotype(s) of the individual marked with a *?

Correct AnswerverifiedShow Answer

A DNA microarray detects

Correct AnswerverifiedShow Answer

Amniocentesis may be preferred over chorionic villus sampling (CVS) for karyotyping because

Correct AnswerverifiedShow Answer

A woman has an X-linked recessive trait. What must her mother's genotype be?

Correct AnswerverifiedShow Answer

Mutant gene alleles associated with known genetic disorders can be detected using DNA microarray analysis.

Correct AnswerverifiedShow Answer

Sickle cell disease and cystic fibrosis both exhibit what mode of inheritance?

Correct AnswerverifiedShow Answer

All sons of a man with a Y-linked disorder will also show the disorder.

Correct AnswerverifiedShow Answer

Ex vivo gene therapy differs from in vivo gene therapy in that

Correct AnswerverifiedShow Answer

In pedigrees of autosomal dominant traits, every affected child must have at least one affected parent.

Correct AnswerverifiedTrue

Figure: -You are a genetic counselor, and a man with the translocation shown in the figure is your client. He and his partner (who has a normal karyotype) wish to have children. You explain to him that the probability of having a child with a normal karyotype is _______.

Correct AnswerverifiedShow Answer

Testing for a protein may help reveal whether or not an individual has a genetic disorder.

Correct AnswerverifiedShow Answer

A parent has a deletion on one homologue of a pair of chromosomes. What is the probability of this individual's child carrying the same deletion?

Correct AnswerverifiedShow Answer

Chorionic villus sampling carries less risk of causing miscarriage than amniocentesis.

Correct AnswerverifiedShow Answer

A pedigree chart is an important tool for a genetic counselor because

Correct AnswerverifiedShow Answer

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